Serum Concentration of Immunoglobulin Classes and Subclasses in Macedonian Elderly People

Meri Kirijas, Slavica Hristomanova, Dejan Trajkov, Milanka Pajkovska, Berislav Kostov, Mirko Spiroski

Abstract


Aim: The aim of this study was to determine the serum concentrations of immunoglobulin classes (IgA, IgM and IgG) and subclasses (IgG1, IgG2, IgG3 and IgG4) in elderly individuals from the Republic of Macedonia.

Material and Methods: This study included elderly persons from the Gerontology Department “13 Noemvri”, Skopje, Republic of Macedonia between the ages of 65 and 101 years, previously screened with the SENIEUR protocol. We investigated the serum concentration of immunoglobulin classes (IgA, IgM and IgG) and subclasses (IgG1, IgG2, IgG3 and IgG4) in these two groups by immunonephelometry.

Results: The results have shown significantly higher concentration in the NON-SENIEUR group for the IgA, IgG, IgG1, and IgG2. Serum concentration of immunoglobulin classes and subclasses in the SENIEUR group have shown significantly higher values in males for IgG, IgG1, and IgG2 and in the NON-SENIEUR group significantly higher values in females for IgG, and IgG1.

Conclusion: Macedonian elderly people from NON-SENIEUR group have shown significantly higher serum concentration of IgA, IgG, IgG1, and IgG2 but without differences in IgM, IgG3 and IgG4. There was gender difference in the serum immunoglobulin concentration between SENIOUR and NONSENIOR elderly group.


Keywords


serum immunoglobulin levels; elderly persons; SENIEUR protocol; Republic of Macedonia

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Copyright (c) 2012 Meri Kirijas, Slavica Hristomanova, Dejan Trajkov, Milanka Pajkovska, Berislav Kostov, Mirko Spiroski

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

  



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