Archives of Public Health

Vol. 9 No. 2 (2017): Archives of Public Health
Clinical Science

Android/legs and legs/trunk indexes determined with dual-energy x-ray absorptiometry in Cushing's and non Cushing's obese women

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  • Славица (Slavica) Шубеска-Стратрова (Shubeska Stratrova),
  • Лидија (Lidija) Тодоровска (Todorovska)
Славица (Slavica) Шубеска-Стратрова (Shubeska Stratrova)
University Clinic of Endocrinology, Diabetes and Metabolic Disorders, University "Ss Cyril and Methodius", Medical Faculty, Skopje
Лидија (Lidija) Тодоровска (Todorovska)
Department of MEP Physiology and Anthropology, University "Ss Cyril and Methodius", Medical Faculty, Skopje

Published 2018-03-17

Keywords

  • Cushing’s syndrome,
  • central obesity,
  • DXA indexes,
  • cut-off points,
  • diagnostic accuracy

How to Cite

1.
Шубеска-Стратрова (Shubeska Stratrova) Славица (Slavica), Тодоровска (Todorovska) Лидија (Lidija). Android/legs and legs/trunk indexes determined with dual-energy x-ray absorptiometry in Cushing’s and non Cushing’s obese women. Arch Pub Health [Internet]. 2018 Mar. 17 [cited 2024 Apr. 20];9(2):18-25. Available from: https://id-press.eu/aph/article/view/1127
Copyright Notice

Abstract

The aim of this study was to evaluate the central obesity, which is a main characteristic of Cushing's syndrome (CS), with dual-energy x-ray absorptiometry (DXA) and to determine DXA indexes that precisely differentiate CS from non CS obese women. In 12 CS women and 12 control obese (CO) with  appropriate BMI which is not significantly different from CS, and 12 healthy control women (C) with normal BMI, following DXA parameters were evaluated: regional (trunk, android and legs) tissue (TM) and fat mass (FM), and also the diagnostic accuracy (DG) for their ratio index cut-off points (CP). The best differentiation of CS from C obtained CP of 0.24 for android/legs TM ratio with DG of 100 %, while CP for legs/trunk TM ratio (0.67) had DG of 95.83 %. Android/legs FM ratio CP of 0.25 differentiated CS from C for DG of 100% and legs/trunk FM ratio of 0.69 differentiated CS from C for DG of 91.67%. Android/legs TM ratio (CP 0.27) and legs/trunk ТМ ratio (CP 0.62) differentiated CS from CO with DG of 87.5%. Conclusion: DXA indexes android/legs and legs/trunk TM and FM discovered extreme central body fat distribution in CS, differentiated them significantly from C and CO, and could be used as DXA indexes of extreme central, abdominal obesity in CS and non CS obese women. Android/legs index had higher DG and predictive value of extreme visceral obesity in CS, compared to legs/trunk index.

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