Archives of Public Health

Vol. 16 No. 1 (2024): Arch Pub Health
Public Health

Antimicrobial susceptibility of Salmonella enteritidis isolated in the period from 2020 to 2022 in the Shtip region

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  • Kristina Sudiklieva,
  • Golubinka Boshevska,
  • Marija Dimitrova,
  • Dragan Kochinski
Kristina Sudiklieva
Faculty of Medical Sciences, Goce Delchev University, Shtip, Republic of North Macedonia
Golubinka Boshevska
Institute of Public Health of the Republic of North Macedonia; Faculty of Medical Sciences, Goce Delchev University, Shtip, Republic of North Macedonia
Marija Dimitrova
Center of Public Health, Shtip, Republic of North Macedonia
Dragan Kochinski
Institute of Public Health of the Republic of North Macedonia; Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, Republic of North Macedonia
DOI: https://doi.org/10.3889/aph.2024.6123

Published 2024-06-25

Keywords

  • infection,
  • food,
  • antimicrobial susceptibility,
  • Salmonella enteritidis

How to Cite

1.
Sudiklieva K, Boshevska G, Dimitrova M, Kochinski D. Antimicrobial susceptibility of Salmonella enteritidis isolated in the period from 2020 to 2022 in the Shtip region . Arch Pub Health [Internet]. 2024 Jun. 25 [cited 2024 Jul. 16];16(1). Available from: https://id-press.eu/aph/article/view/6123

Copyright (c) 2024 Kristina Sudiklieva, Golubinka Boshevska, Marija Dimitrova, Dragan Kochinski

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Bacteria of the genus Salmonella are widely distributed in nature. They can colonize different hosts and are the most common causes of intestinal infections in humans and animals. The main route of Salmonella transmission to humans is by contaminated food, or undercooked eggs and meat. The aim of this study was to analyze the antimicrobial susceptibility of Salmonella enteritidis, which was the most frequently isolated Salmonella in the Microbiological Laboratory of the Center of Public Health in Shtip. Materials and methods: A total of 1839 samples (12 rectal swabs and 1827 feces),   from persons suspect for salmonellosis in the region of Shtip were investigated for the period 2020 to 2022 year.  SS (Salmonella Shigella) agar, Rambach agar, and Selenit F media  were used for detection of Salmonella spp., and antimicrobial susceptibility testing of the isolated bacteria is performed  with disk diffusion method according EUCAST.  Results: Salmonella enteritidis is detected in 62 samples (3.37%), isolated strains of Salmonella enteritidis demonstrate high resistance to ampicillin 2 μg (37.09%), and multi-resistant strains (6.45%) were also detected.  Conclusion: The appearance of ampicillin and multi-resistant strains of Salmonella enteritidis in the samples analyzed in our study is a sign of concern and an alarm to initiate a change in the algorithm for the treatment of Salmonella enteritidis infections, especially with the use of fluoroquinolones and cephalosporins (of the third generation). It is recommended to introduce a system for the rational use of antimicrobials in human and veterinary health.

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References

  1. References
  2. Sanchez S, Hofacre CL, Lee MD, Maurer JЈ, Doyle M. Animal sources of salmonellosis in humans. J Am Vet Med Assoc. 2002;221(4):492-497 DOI: 10.2460/javma.2002.221.492
  3. Shinohara NKS, Bezerra de Barros V, Jimenez SMC, Machado ECL, Fireman Dutra RA, Filho JL. Salmonella spp important pathogenic agent transmitted through foodstuffs. Cien Saude Colet. 2008; 13(5):1675-1683 DOI: 10.1590/s1413-81232008000500031
  4. Anderson D.Hohmann EL. Nontypoidal Salmonellosis. Clinical infection disease 2001;32(2):263-269 DOI: 10.1086/318457
  5. Извештај за здравјето и здравствената заштита на населението во Република Северна Македонија во 2022, Институт за јавно здравје на Република Северна Македонија https://www.iph.mk/Upload/Documents/Izvestaj%20za%20zdravje%202022.pdf. 2022.
  6. EUCAST, European Committee on Antimicrobial Susceptibility Testing, Clinical breakpoints - breakpoints and guidance 2023.https://www.eucast.org/clinical_breakpoints
  7. European Centre for Disease Prevention and Control. Ongoing clusters of Salmonella Enteritidis ST11 linked to consumption of chicken meat, Threats and outbreaks of salmonellosis, November 2022
  8. European Food Safety Authority (EFSA), European Centre for Disease Prevention and Control (ECDC). The European Union One Health 2021. Zoonoses Report: EFSA,ECDC, 2021,2022.https://www.ecdc.europa.eu/en/infectious-diseases-and-public-health/salmonellosis/threats-and-outbreaks
  9. European Food Safety Authority (EFSA); Antimicrobial resistance - Data visualisation tool, 2021 https://multimedia.efsa.europa.eu/dataviz-2021/index.htm
  10. Alcaine SD, Warnick LD, Wiedmann M. Antimicrobial resistance in nontyphoidal Salmonella. J Food Prot 2007; 70 (3): 780–790 DOI: 10.4315/0362-028x-70.3.780
  11. Kaichao C, Donga N, Edward WCh, Chena S. Transmission of ciprofloxacin resistance in Salmonella mediated by a novel type of conjugative helper plasmids. Emerg Microbes Infect. 2019; 8 (1): 857-865 DOI: 10.1080/22221751.2019.1626197
  12. Adzitey F. Antibiotic resistance of Escherichia coli and Salmonella enterica isolated from cabbage and lettuce samples in Tamale metropolis of Ghana. International Journal of Food Contamination. 2018; 5,7.DOI: https://doi.org/10.1186/s40550-018-0068-z
  13. Carattoli A. Plasmid-mediated antimicrobial resistance in Salmonella enterica. Curr Issues Mol Biol. 2003;5(4):113-122 PMID:12921226
  14. Commission notice, Guidelines for the prudent use of antimicrobials in veterinary medicine, (2015/C 299/04). Official Journal of the European Union. 2015; C 299/7 - C 299/26 DOI: https://doi.org/10.1016/j.ejps.2023.106473

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