AbstractThyroid clearance of J-131 and Tc-99m after simultaneous subcutaneous injection in rats were estimated in the early phase. Arterial blood samples were drawn with a polyethene catheter inserted in the iliac artery in intervals of two minutes. The animals were sacrificed at the 20th minute and the wet weight of the thyroid gland was estimated. Tc-99m activity was counted on a ring counter consisting of GM tubes. The activity of J-131 was measured after the decay of Tc-99m. On and Tc-99m were identical which suggests that the subcutaneous way of Tc-99m application alters the pertechnetate state of the compound very similar to the oral route of Tc-99m pertechnetate application.
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