Улога на метаболичниот синдром во развој и прогресија на хроничната бубрежна слабост

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Tatjana Barjaktarova Prosheva
Liljana Tozija

Апстракт

Метаболичкиот Ñиндром Ñтанува Ñе поголем здравÑтвен проблем во Ñветот, како во земјите во развој така и во виÑоко развиените земји. Познато е дека компонентите на метаболичкиот Ñиндром (обезноÑÑ‚, хипертензија, хиперлипидемија и инÑулинÑка резиÑтенција) ја зголемуваат инциденцата, а Ñо тоа и морбидитетот и морталитетот на кардиоваÑкуларните заболувања. ПоÑтојат Ñтудии кои укажуваат и на аÑоцијација на метаболичкиот Ñиндром Ñо развојот и прогреÑијата на хроничната бубрежна болеÑÑ‚. Корелацијата на поединечните ентитети на метаболичкиот Ñиндром како што е хипертензијата и инÑулинÑката резиÑтенција Ñо поÑледователен развој на тип 2 Ð´Ð¸Ñ˜Ð°Ð±ÐµÑ‚ÐµÑ Ð¼ÐµÐ»Ð¸Ñ‚ÑƒÑ, Ñо развојот на хроничната бубрежна ÑлабоÑÑ‚ е добро позната, но Ñеуште има дилеми и Ñе диÑкутира за ефектот на метаболичкиот Ñиндром како целина врз нарушувањето на бубрежната функција. Во можните механизми кои ја оштетуваат бубрежната функција Ñе вбројуваат инÑулинÑката резиÑтенција и окÑидативниот ÑтреÑ, микроваÑкуларното оштетување и иÑхемја на бубрезите.

Целта на овој прегледен труд е да Ñе ÑиÑтематизираат податоците добиени од Ñтудиите кои укажуваат на поврзаноÑÑ‚ на овие две патолошки ÑоÑтојби за подобро да Ñе разбере како компонентите на метаболичкиот Ñиндром влијаат на прогреÑијата на хроничната бубрежна болеÑÑ‚, намалувањето на гломеруларната филтрациона рата и патофизиолошките промени на бубрезите аÑоцирани Ñо метаболички Ñиндром.

Во трудот Ñе опфатени понови Ñознанија и наоди и нивна примена во третманот на метаболичкиот Ñиндром аÑоциран Ñо ХББ што вклучува редукција на телеÑна тежина, промена на животниот Ñтил Ñо Ñоодветно модифицирана диета и физичка активноÑÑ‚.

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Како да се цитира
Barjaktarova Prosheva, T., & Tozija, L. (2015). Улога на метаболичниот синдром во развој и прогресија на хроничната бубрежна слабост. Македонско медицинско електронско списание, 2015, 1–9. https://doi.org/10.3889/mmej.2015.50005
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