Современи погледи на хомеостазата на железо со основен акцент на хепцидинот – новиот хормон, регулатор на метаболизмот на железо

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Biljana Ilkovska
Bisera Kotevska
Georgi Trifunov

Апстракт

Железото е еÑенцијален елемент за Ñкоро Ñите живи организми. Тој е клучен функционален дел на киÑлородните транÑпортери, депонирачките молекули и многу ензими кои ја катализираат Ñ€ÐµÐ´Ð¾ÐºÑ Ñ€ÐµÐ°ÐºÑ†Ð¸Ñ˜Ð°Ñ‚Ð° неопходна за генерирање на енергија, продукти на различни метаболички интермедиери и за одбрана. ИÑтражувањата покажаа дека клучен регулатор во хомеоÑтазата на железото е хепцидинот и го поÑтавија црниот дроб за централен орган во ÑиÑтемÑката хомеоÑтаза на железото. Хепцидинот е катјонÑки пептид ÑоÑтавен од 25 амино киÑелини и 4 диÑулфидни врÑки. Ðеодамна беше откриено дека циркулирачкиот хепцидин Ñо релативно виÑок афинитет е врзан за α2-макроглобулин и Ñо релативно низок афинитет Ñо албуминот. Во прилог на Ñвојата улога во регулирањето на ÑиÑтемÑкиот метаболизам на железо, хепцидинот може да придонеÑе за одбраната на домаќинот. Хепцидинот првично беше идентификуван како антимикробен пептид и беше откриено дека може индиректно да придонеÑе за одбраната на домаќинот преку намалување на концентрацијата на железо во плазмата.

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Ilkovska, B., Kotevska, B., & Trifunov, G. (2015). Современи погледи на хомеостазата на железо со основен акцент на хепцидинот – новиот хормон, регулатор на метаболизмот на железо. Македонско медицинско електронско списание, 2015, 1–14. https://doi.org/10.3889/mmej.2015.50010
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