Техники и методи за детекција и дијагноза на орални премалигни и малигни лезии

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Bruno Nikolovski
Danica Popovic Monevska
Ana Minovska
Mirjana Popovska
Vera Radojkova Nikolovska

Апстракт

ОСÐОВÐ: Оралните премалигни и малигни лезии бележат тенденција на доцна детекција, која е на штета на пациентите поради виÑоките Ñтапки на морбидитет и морталитет.. Токму затоа е важно раното дијагноÑтицирање на овие нарушувања и заболувања.

ЦЕЛ: Целта на овој труд е да ги евалуираме дијагноÑтичките ÑредÑтва и методи за детекција на премалигните и малигни орални лезии.

ÐœÐТЕРИЈÐЛ И МЕТОДИ: За изработка на овој труд, Ñпроведовме автоматÑко детално пребарување на интернет базата PubMed за периодот од 1966 година до 2014 година. Клучни зборови Ñпоред кои го изведовме пребарувањето беа: "орални преканцерози, орален карцином, визуелни ÑредÑтва и молекуларни биолошки маркери". Ги вклучивме и извештаите кои беа рецензирани и прифатени за објавување, а Ñеуште неиÑпечатени. Ги иÑклучивме Ñтатиите кои беа извеÑтувања од екÑперти, како и оние кои не беа од англиÑко издание или не беа изведени на хумани Ñубјекти.

РЕЗУЛТÐТИ: Од најчеÑто употребуваните техники и дијагноÑтички теÑтови, виталните ткивни боења покажуваат ÑензитивноÑÑ‚ од 93.5% – 97.8% и нешто пониÑка ÑпецифичноÑÑ‚ од 73.3% - 92.9%. Употребата на Ñовремените алатки за визуелизација на ткивните аберации, бележат ÑензитивноÑÑ‚ од околу 30% и ÑпецифичноÑÑ‚ од 63%.

ЗÐКЛУЧОК: Оралната цитологија, патохиÑтолошкиот наод, молекуларните биолошки иÑпитувања, како и примената на ÑофиÑтицирани визуелни ÑредÑтва во детекција на ÑуÑпектните орални лезии, Ñе Ñмета дека ќе доведат до рано дијагноÑтицирање и ќе го направи толкувањето на наодите далеку поÑигурно отколку порано.

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Nikolovski, B., Popovic Monevska, D., Minovska, A., Popovska, M., & Radojkova Nikolovska, V. (2015). Техники и методи за детекција и дијагноза на орални премалигни и малигни лезии. Македонско медицинско електронско списание, 2015, 1–8. https://doi.org/10.3889/mmej.2015.50016
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