Experimental Study of the New Non-Opioid Analgesic Pyrodazol and Ketorolac in the Rats

Abstract

Aim: To search the new analgesics we studied the antinociceptive activity of the new derivative 5H-pyrrolo [1,2-a]¬imidazole in comparison with this of the morphine and ketorolac.

Material and Methods: The analgesia was evaluated on hot plate and tail-flick thermal nociceptive stimulation models by intragastric administration of ketorolac and by intramuscular injection of morphine.

Results: On the hot plate model ED₅₀ value was per body weight 0.34 (0.18 - 0.63) mg/kg of the pyrodazol /i.g, 1.00 (0.59 - 1.70) mg/kg/of the ketorolac/ i. g. in 90 minutes post administration. On the hot plate model in 0.3 - 1.3 mg/kg/doses i.m the pirodazol is similar to morphine hydrochloride in dose 2.5 mg/kg i.m. On the tail-flick model ED₅₀ values of the pyrodazol and ketorolac are 1.9 (1.12 - 3.23) mg/kg /i.g and 3.0 (2.08 - 4.32) mg/kg/i. g, respectively.

Conclusion: The obtained data may allow to suggest that on thermal nociceptive stimulation models the pyrodazol exceeds the ketorolac and on the hot plate models it is similar to the morphine hydrochloride.