Distribution of Killer Cell Immunoglobulin-Like Receptor Genes in Albanians from Republic of Macedonia

Article Sidebar

PDF
Published: Feb 19, 2015
DOI: https://doi.org/10.3889/seejhg.2015.40001
Keywords:
Killer immunoglobulin-like receptor (KIR) gene polymorphism, KIR genotyping, PCR-SSP, Albanians from Macedonia

Main Article Content

Aleksandar Petlichkovski
Institute of Immunobiology and Human Genetics, Faculty of Medicine, Ss. Cyril and Methodius University of Skopje, Skopje
Eli Djulejic
PAREXEL International Serbia, Takovska 46A, Belgrade 11070
Dejan Trajkov
Institute of Immunobiology and Human Genetics, Faculty of Medicine, Ss. Cyril and Methodius University of Skopje, Skopje
Olivija Efinska-Mladenovska
Institute of Immunobiology and Human Genetics, Faculty of Medicine, Ss. Cyril and Methodius University of Skopje, Skopje
Slavica Hristomanova Mitkovska
Institute of Immunobiology and Human Genetics, Faculty of Medicine, Ss. Cyril and Methodius University of Skopje, Skopje
Mirko Spiroski
Institute of Immunobiology and Human Genetics, Faculty of Medicine, Ss. Cyril and Methodius University of Skopje, Skopje

Abstract

AIM: The aim of this study was to analyze Killer Ig-Like Receptor (KIR) gene polymorphisms in Albanians from Republic of Macedonia.

MATERIAL NA METHODS: The studied sample consists of 104 healthy unrelated individuals, aged 20-45 years. All individuals are of Albanian nationality, residents of different geographical regions (Skopje, Gostivar, and Tetovo) in Republic of Macedonia. The population genetics analysis package, Arlequin, was used for analysis of the data.

RESULTS: All 16 KIR genes known were observed in the Albanian individuals and framework genes (KIR3DL3, KIR3DP1, KIR2DL4, and KIR3DL2) were present in all individuals. The frequencies of other KIR genes were: KIR2DP1 (0.981), KIR2DL1 (1), KIR2DL2 (0.615), KIR2DL3 (0.865), KIR2DL5 (0.414), KIR3DL1 (0.933), KIR2DS1 (0.462), KIR2DS2 (0.606), KIR2DS3 (0.327), KIR2DS4 (0.875), KIR2DS5 (0.298), and KIR3DS1 (0.442). Tested linkage disequilibrium (LD) among KIR genes demonstrated that KIR genes present a wide range of linkage disequilibrium.

CONCLUSION: This is the first study analyzing the polymorphism of KIR genes and genotype frequencies in Albanian individuals in the world. The results can be used for anthropological comparisons.

 

Downloads

Download data is not yet available.

Article Details

Issue
Vol. 2015 (2015): SEE J Hum Genet
Section
Population Genetics
Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

References

Demiraj S. The Origin of Albanians. Academy of Sciences of Albania, Tirana, 2006.

Albanian Agency for Statistics, 2011 Albania Census. Retreived June, 2012 from: https://www.cia.gov/library/publications/the-world-factbook/geos/al.html

Kosovo Agency for Statistics, 2011 Kosovo Census, Retreived June, 2012 from: http://esk.rks-gov.net/rekos2011/?cid=2,40,276

Macedonia, S. S. O. o. t. R. o. Census 2002: Total population of the Republic of Macedonia according to declared ethnic affiliation, Skopje, 2004.

Grubić Z, Kerhin-Brkljacić V, Cecuk-Jelicić E, Kuci S, Kastelan A. HLA class I polymorphism in the Albanian population. Coll Antropol. 2000;24(2):303-7.

Sulcebe G, Sanchez-Mazas A, Tiercy JM, Shyti E, Mone I, Ylli Z, Kardhashi V. HLA allele and haplotype frequencies in the Albanian population and their relationship with the other European populations. Int J Immunogenet. 2009;36(6):337-43.

Boattini A, Luiselli D, Sazzini M, Useli A, Tagarelli G, Pettener D. Linking Italy and the Balkans. A Y-chromosome perspective from the Arbereshe of Calabria. Ann Hum Biol. 2011;38(1):59-68.

Plaseski T, Noveski P, Popeska Z, Efremov GD, Plaseska-Karanfilska D. Association Study of Single-Nucleotide Polymorphisms in FASLG, JMJDIA, LOC203413, TEX15, BRDT, OR2W3, INSR, and TAS2R38 Genes With Male Infertility. J Androl. 2012;33(4):675-83.

Ferri G, Tofanelli S, Alù M, Taglioli L, Radheshi E, Corradini B, Paoli G, Capelli C, Beduschi G. Y-STR variation in Albanian populations: implications on the match probabilities and the genetic legacy of the minority claiming an Egyptian descent. Int J Legal Med. 2010;124(5):363-70.

Belledi M, Poloni ES, Casalotti R, Conterio F, Mikerezi I, Tagliavini J, Excoffier L. Maternal and paternal lineages in Albania and the genetic structure of Indo-European populations. Eur J Hum Genet. 2000;8(7):480-6.

Kruja J, Beghi E, Zerbi D, Dobi D, Kuqo A, Zekja I, Mijo S, Kapisyzi M, Messina P. High prevalence of major neurological disorders in two Albanian communities: results of a door-to-door survey. Neuroepidemiology. 2012;38(3):138-47.

Festini F, Taccetti G, Repetto T, Mannini C, Neri S, Bisogni S, de Martino M. Incidence of cystic fibrosis in the Albanian population. Pediatr Pulmonol. 2008;43(11):1124-9.

Castaman G, Giacomelli SH, Ghiotto R, Boseggia C, Pojani K, Bulo A, Madeo D, Rodeghiero F. Spectrum of mutations in Albanian patients with haemophilia A: identification of ten novel mutations in the factor VIII gene. Haemophilia. 2007;13(3):311-6.

Harel-Bellan A, Quillet A, Marchiol C, DeMars R, Tursz T, Fradelizi D. Natural killer susceptibility of human cells may be regulated by genes in the HLA region on chromosome 6. Proc Natl Acad Sci U S A. 1986;83(15):5688-92.

Moretta A, Tambussi G, Bottino C, Tripodi G, Merli A, Ciccone E, Pantaleo G, Moretta L. A novel surface antigen expressed by a subset of human CD3- CD16+ natural killer cells. Role in cell activation and regulation of cytolytic function. J Exp Med. 1990;171(3):695-714.

Liu WR, Kim J, Nwankwo C, Ashworth LK, Arm JP. Genomic organization of the human leukocyte immunoglobulin-like receptors within the leukocyte receptor complex on chromosome 19q13.4. Immunogenetics. 2000;51(8-9):659-69.

Gonzalez A, McErlean C, Meenagh A, Shovlin T, Middleton D. Killer cell immunoglobulin-like receptor allele discrimination by high-resolution melting. Hum Immunol. 2009;70(10):858-63.

Uhrberg M, Valiante NM, Shum BP, Shilling HG, Lienert-Weidenbach K, Corliss B, Tyan D, Lanier LL, Parham P. Human diversity in killer cell inhibitory receptor genes. Immunity. 1997;7(6):753-63.

Middleton D, Gonzelez F. The extensive polymorphism of KIR genes. Immunology. 2010;129(1):8-19.

Towner P. Purification of DNA. Essential Molecular Biology. Ed by Brown TA. Oxford, Oxford University Press, 1995: 47-54.

Spiroski M, Arsov T, Petlichkovski A, Strezova A, Trajkov D, Efinska-Mladenovska O, Zaharieva E. Case Study: Macedonian Human DNA Bank (hDNAMKD) as a source for public health Genetics. Health Determinants in the Scope of New Public Health. B. G. Georgieva L. Sofia, Hans Jacobs, 2005.

Marsh SG, Parham P, Dupont B, Geraghty DE, Trowsdale J, Middleton D, Vilches C, Carrington M, Witt C, Guethlein LA, Shilling H, Garcia CA, Hsu KC, Wain H. Killer-cell immunoglobulin-like receptor (KIR) nomenclature report, 2002. Immunogenetics. 2003;55(4):220-6.

Robinson J, Mistry K, McWilliam H, Lopez R, Marsh SG. IPD--the Immuno Polymorphism Database. Nucleic Acids Res. 2010;38(Database issue):D863-9.

Gómez-Lozano N, Vilches C. Genotyping of human killer-cell immunoglobulin-like receptor genes by polymerase chain reaction with sequence-specific primers: an update. Tissue Antigens. 2002;59(3):184-93.

Excoffier L, Laval G, Schneider S. Arlequin (version 3.0): an integrated software package for population genetics data analysis. Evol Bioinform Online. 2007;1:47-50.

Mattuiz PL, Ihde D, Piazza A, Ceppellini R, Bodmer WF. New approaches to population genetics and segregation analysis of the HLA system. In: TerasakiPI, editor. Histocompatibility testing. Copenhagen: Munksgaard; 1970. p. 193–205.

Lewontin RC, Dunn LC. The Evolutionary Dynamics of a Polymorphism in the House Mouse. Genetics. 1960;45(6):705-22.

Lewontin RC. The Interaction of Selection and Linkage. I. General Considerations; Heterotic Models. Genetics. 1964;49(1):49-67.

Djulejic E, Petlichkovski A, Trajkov D, Hristomanova S, Middleton D, Spiroski M. Distribution of killer cell immunoglobulinlike receptors in the Macedonian population. Hum Immunol. 2010;71(3):281-8.

Gonzalez-Galarza FF, Christmas S, Middleton D, Jones AR. Allele frequency net: a database and online repository for immune gene frequencies in worldwide populations. Nucleic Acids Res. 2011;39(Database issue):D913-9.

Gourraud PA, Gagne K, Bignon JD, Cambon-Thomsen A, Middleton D. Preliminary analysis of a KIR haplotype estimation algorithm: a simulation study. Tissue Antigens. 2007;69 Suppl 1:96-100.

Denis L, Sivula J, Gourraud PA, Kerdudou N, Chout R, Ricard C, Moisan JP, Gagne K, Partanen J, Bignon JD. Genetic diversity of KIR natural killer cell markers in populations from France, Guadeloupe, Finland, Senegal and Réunion. Tissue Antigens. 2005;66(4):267-76.

Bontadini A, Testi M, Cuccia MC, Martinetti M, Carcassi C, Chiesa A, Cosentini E, Dametto E, Frison S, Iannone AM, Lombardo C, Malagoli A, Mariani M, Mariotti L, Mascaretti L, Mele L, Miotti V, Nesci S, Ozzella G, Piancatelli D, Romeo G, Tagliaferri C, Vatta S, Andreani M, Conte R. Distribution of killer cell immunoglobulin-like receptors genes in the Italian Caucasian population. J Transl Med. 2006;4:44.

Niokou D, Spyropoulou-Vlachou M, Darlamitsou A, Stavropoulos-Giokas C. Distribution of killer cell immunoglobulin-like receptors in the Greek population. Hum Immunol. 2003;64(12):1167-76.

Verheyden S, Bernier M, Demanet C. Identification of natural killer cell receptor phenotypes associated with leukemia. Leukemia. 2004;18(12):2002-7.

Cook MA, Moss PA, Briggs DC. The distribution of 13 killer-cell immunoglobulin-like receptor loci in UK blood donors from three ethnic groups. Eur J Immunogenet. 2003;30(3):213-21.

Suzuki Y, Hamamoto Y, Ogasawara Y, Ishikawa K, Yoshikawa Y, Sasazuki T, Muto M. Genetic polymorphisms of killer cell immunoglobulin-like receptors are associated with susceptibility to psoriasis vulgaris. J Invest Dermatol. 2004;122(5):1133-6.

Petlichkovski A, Djilejic E, Trajkov D, Efinska-Mladenovska O, Hristomanova S, Kirijas M, Senev A, Spiroski M. Distribution of killer cell immunoglobulin-like receptor genes in Roma from Republic of Macedonia. Int J Immunogenet. 2011; 38 (6) 493-500

Norman PJ, Carrington CV, Byng M, Maxwell LD, Curran MD, Stephens HA, Chandanayingyong D, Verity DH, Hameed K, Ramdath DD, Vaughan RW. Natural killer cell immunoglobulin-like receptor (KIR) locus profiles in African and South Asian populations. Genes Immun. 2002;3(2):86-95.

Rajalingam R, Krausa P, Shilling HG, Stein JB, Balamurugan A, McGinnis MD, Cheng NW, Mehra NK, Parham P. Distinctive KIR and HLA diversity in a panel of north Indian Hindus. Immunogenetics. 2002;53(12):1009-19.

Spiroski M, Milenkovic Z, Petlichkovski A, Ivanovski L, Topuzovska IK, Djulejic E. Killer cell immunoglobulin-like receptor genes in four human West Nile virus infections reported 2011 in the Republic of Macedonia. Human immunology. 2013; 74(3), 389-394.

Petlichkovski A, Stojanoski Z, Djulejic E, Georgievski B, Spiroski M. Association of Killer Cell Immunoglobulin-Like Receptor Genes with the Graft versus Host Disease after Related Haematopoietic Stem Cell Transplantation in Patients with Haematological Malignancies from Republic of Macedonia. Maced J Med Sci. 2012; 5(4):404-410.

Petlichkovski A, Milenkovic Z, Djulejic E, Jefremovska B, Babacic H, Ivanovski LJ, Kondova Topuzovska I, Spasovska K, Spiroski M. Association of Killer Cell Immunoglobulin-Like Receptor Genes with Pandemic Influenza A (H1N1)pdm09 Infection in Critically Ill Macedonian Patients. Maced J Med Sci. 2012; 5(3):288-295.

Petlichkovski A, Stojanoski Z, Cibrev D, Spiroski M. Killer Cell Immunoglobulin-Like Receptor Genes Polymorphisms in Macedonian Patients with Haematological Malignancies. Maced J Med Sci. 2013; 6(1):24-30.

Djulejic E, Petlichkovski A, Trajkov D, Dimitrov G, Alabakovska S. KIR Gene Frequencies in Women with Infertility Problems. SEE J Immunol. 2015; 2015:20002.

Single RM, Martin MP, Gao X, Meyer D, Yeager M, Kidd JR, Kidd KK, Carrington M. Global diversity and evidence for coevolution of KIR and HLA. Nat Genet. 2007;39(9):1114-9.

Middleton DAM, Serrano-Vela JI, Moscosoc J, Antonio Arnaiz-Villena A. Different Evolution of Inhibitory and Activating Killer Immunoglobulin Receptors (KIR) in Worldwide Human Populations. Open Immunol J. 2008;1:42-50.