Distribution of Killer Cell Immunoglobulin-Like Receptor Genes in Albanians from Republic of Macedonia

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Published: Feb 19, 2015
DOI: https://doi.org/10.3889/seejhg.2015.40001
Keywords:
Killer immunoglobulin-like receptor (KIR) gene polymorphism, KIR genotyping, PCR-SSP, Albanians from Macedonia

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Aleksandar Petlichkovski
Institute of Immunobiology and Human Genetics, Faculty of Medicine, Ss. Cyril and Methodius University of Skopje, Skopje
Eli Djulejic
PAREXEL International Serbia, Takovska 46A, Belgrade 11070
Dejan Trajkov
Institute of Immunobiology and Human Genetics, Faculty of Medicine, Ss. Cyril and Methodius University of Skopje, Skopje
Olivija Efinska-Mladenovska
Institute of Immunobiology and Human Genetics, Faculty of Medicine, Ss. Cyril and Methodius University of Skopje, Skopje
Slavica Hristomanova Mitkovska
Institute of Immunobiology and Human Genetics, Faculty of Medicine, Ss. Cyril and Methodius University of Skopje, Skopje
Mirko Spiroski
Institute of Immunobiology and Human Genetics, Faculty of Medicine, Ss. Cyril and Methodius University of Skopje, Skopje

Abstract

AIM: The aim of this study was to analyze Killer Ig-Like Receptor (KIR) gene polymorphisms in Albanians from Republic of Macedonia.

MATERIAL NA METHODS: The studied sample consists of 104 healthy unrelated individuals, aged 20-45 years. All individuals are of Albanian nationality, residents of different geographical regions (Skopje, Gostivar, and Tetovo) in Republic of Macedonia. The population genetics analysis package, Arlequin, was used for analysis of the data.

RESULTS: All 16 KIR genes known were observed in the Albanian individuals and framework genes (KIR3DL3, KIR3DP1, KIR2DL4, and KIR3DL2) were present in all individuals. The frequencies of other KIR genes were: KIR2DP1 (0.981), KIR2DL1 (1), KIR2DL2 (0.615), KIR2DL3 (0.865), KIR2DL5 (0.414), KIR3DL1 (0.933), KIR2DS1 (0.462), KIR2DS2 (0.606), KIR2DS3 (0.327), KIR2DS4 (0.875), KIR2DS5 (0.298), and KIR3DS1 (0.442). Tested linkage disequilibrium (LD) among KIR genes demonstrated that KIR genes present a wide range of linkage disequilibrium.

CONCLUSION: This is the first study analyzing the polymorphism of KIR genes and genotype frequencies in Albanian individuals in the world. The results can be used for anthropological comparisons.

 

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Conference Proceedings Volume
Vol. 2015 (2015): SEE J Hum Genet
Section
Population Genetics
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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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