Vol. 9 No. 2 (2017): Archives of Public Health
Clinical Science

Clinical course and out- come in patients with early diagnosed CAKUT

Наташа (Natasha) Алулоска (Aluloska)
Универзитетска клиника за детски болести, Медицински факултет, Скопје
Илија (Ilija) Кировски (Kirovski)
Универзитетска клиника за детски болести, Медицински факултет, Скопје
Анет (Anet) Папазовска-Черепналковски (Papazovska-Cherepnalkovski)
Клиника за акушерија и гинекологија, Клинички центар, Медицински факултет, Сплит
Снежана (Snezhana) Палчевска (Palchevska)
Клиничка болница Аџибадем Систина, Скопје
Христина (Hristina) Бицевска-Манџуковска (Bicevska-Mandzukovska)
Универзитетска клиника за детски болести, Медицински факултет, Скопје
Гордана (Gordana) Китева-Тренчевска (Kiteva-Trenchevska)
Универзитетска клиника за неврологија, Медицински факултет, Скопје
Велибор (Velibor) Тасиќ (Tasic)
Универзитетска клиника за детски болести, Медицински факултет, Скопје

Published 2018-03-17

Keywords

  • malformations,
  • kidneys,
  • urinary tract,
  • clinical course,
  • outcome

How to Cite

1.
Алулоска (Aluloska) Наташа (Natasha), Кировски (Kirovski) Илија (Ilija), Папазовска-Черепналковски (Papazovska-Cherepnalkovski) Анет (Anet), Палчевска (Palchevska) Снежана (Snezhana), Бицевска-Манџуковска (Bicevska-Mandzukovska) Христина (Hristina), Китева-Тренчевска (Kiteva-Trenchevska) Гордана (Gordana), Тасиќ (Tasic) Велибор (Velibor). Clinical course and out- come in patients with early diagnosed CAKUT. Arch Pub Health [Internet]. 2018 Mar. 17 [cited 2024 Mar. 28];9(2):5-11. Available from: https://id-press.eu/aph/article/view/1358

Abstract

Congenital anomalies of the kidney and urinary tract- CAKUT are common childhood pathology accounting for 20-30% of all perinatally detected congenital anomalies. The importance of CAKUT is the risk they represent to kidney function deterioration and end-stage renal disease development.

The aim of this study was to analyze the clinical course and outcome in patients with early diagnosed CAKUT. The study was designed as retrospective observational study.  A total of 100 patients with early diagnosed CAKUT at University Children's Hospital, Skopje, were enrolled in the study. The results obtained in this study present the clinical course and outcome in the study group. Urinary tract  infections were seen in 30% of patients enrolled in this study; they were predominantly girls (65%), mostly  diagnosed with posterior urethral  valve, VUR (vesicouretral reflux) and UPJO (ureteropelviuc junction obstruction). Surgical treatment  was required in 28% of patients, and chronic renal failure was diagnosed in 4% of the total number of patients in this study.

This study aims to contribute to understanding the early diagnosed CAKUT as well as to establishing a protocol for early detection and adequate treatment in order to prevent renal function deterioration.

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References

  1. Hattori S, Yosioka K, Honda M et al. The 1998 report of the Japanese National Registry data on pediatric end-stage renal disease patients. Pediatr Nephrol 2002:17; 456–461
  2. Moritz KM, Singh RR, Probyn ME et al. Developmental programming of a reduced nephron endowment: more than just a baby's birth weight. Am J Physiol Renal Physiol 2009: 296; F1–F9
  3. Queisser-Luft A, Stolz G, Wiesel A, Schlaefer K, Spranger J. Malformations in newborn: results based on 30,940 infants and fetuses from the Mainz congenital birth defect monitoring system (1990-1998). Arch Gynecol Obstet. 2002:266(3);163
  4. Wiesel A, Queisser-Luft A, Clementi M, Bianca S, Stoll C, EUROSCAN Study Group. Prenatal detection of congenital renal malformations by fetal ultrasonographic examination: an analysis of 709,030 births in 12 European countries. Eur J Med Genet. 2005:48(2);131
  5. Livera LN, Brookfield DS, Egginton JA, Hawnaur JM. Antenatal ultrasonography to detect fetal renal abnormalities: a prospective screening programme". BMJ. 1989:298(6685);1421
  6. Reuss A, Wladimiroff JW, Niermeijer MF. Antenatal diagnosis of renal tract anomalies by ultrasound. Pediatr Nephrol. 1987:1(3);546
  7. Song R, Yosypiv I. V. Genetics of congenital anomalies of the kidney and urinary tract. Pediatric Nephrology. 2011:26(3);353–364
  8. Schedl A. Renal abnormalities and their developmental origin. Nat Rev Genet 2007:8; 791–802
  9. Rosborough AD, Luger AM, Nolph KD. Familial unilateral renal agenesis and focal and segmental glomerulosclerosis. American Journal of Kidney Diseases. 1993:21(6); 663–668
  10. Murugasu B, Cole RB, Hawkins EP, Blanton SH, Conley SB, Portman RJ. Familial renal adysplasia. American Journal of Kidney Diseases, 1991:18(4); 490– 494
  11. Eccles MR, Bailey RR, Abbott GD, Sullivan MJ. Unravelling the genetics of vesicoureteric reflux: a common familial disorder. Human Molecular Genetics. 1996:5;1425–1429
  12. Ardissino G, Daccò V, Testa S, Bonaudo R, Claris Appiani A, Taioli E, MarraG, Edefonti A, Sereni F, ItalKid Project. Epidemiology of chronic renal failure in children: Data from the ItalKid project. Pediatrics. 2003:111; e382–e387
  13. González Celedón C, Bitsori M, Tullus K. Progression of chronic renal failure in children with dysplastic kidneys. Pediatr Nephrol. 2007:22;1014–1020
  14. Sanna-Cherchi S, Ravani P, Corbani V, Parodi S, Haupt R, Piaggio G, et al. Renal outcome in patients with congenital anomalies of the kidney and urinary tract. Kidney Int. 2009:76;528–533
  15. Groothoff JW. Long-term outcomes of children with end-stage renal disease. Pediatr Nephrol. 2005; 20: 849–853
  16. James MT, Hemmelgarn BR, Tonelli M. Early recognition and prevention of chronic kidney disease. Lancet. 2010; 375: 1296–1309
  17. Schwartz GJ, Brion LP, Spitzer A.: The use of plasma creatinine concentration for estimating glomerular filtration rate in infants, children, and adolescents. Pediatr Clin North Am. 1987:34; 571–590
  18. Wiesel A, Queisser-Luft A, Clementi M, Bianca S, Stoll C. EUROSCAN Study Group. Prenatal detection of congenital renal malformations by fetal ultrasonographic examination: An analysis of 709,030 births in 12 European Countries. Eur J Med Genet. 2005:48;131–44
  19. Sifhu G et al. Outcome of isolated antenatal hydronephrosis: a systematic review and meta-analysis. Pediatr Nephrol. 2006:21;218–224
  20. Nguyen HT, Herndon CD, Cooper C, Gatti J, Kirsch A, Kokorowski P, Lee R, Perez-Brayfield M, Metcalfe P, Yerkes E, Cendron M, Campbell JB.: The Society for Fetal Urology consensus statement on the evaluation and management of antenatal hydronephrosis. J Pediatr Urol. 2010:6; 212–231
  21. Mallik M, Watson AR.: Antenatally detected urinary tract abnormalities: More detection but less action. Pediatr Nephrol. 2008:23;897–904
  22. Lee JH, Choi HS, Kim JK, Won HS, Kim KS, Moon DH, Cho KS, Park YS.: Nonrefluxing neonatal hydronephrosis and the risk of urinary tract infection. J Urol. 2008:179;1524–1528
  23. Walsh TJ, Hsieh S, Grady R, Mueller BA: Antenatal hydronephrosis and the risk of pyelonephritis hospitalization during the first year of life. Urology 2007:69; 970–974
  24. Quirino I, Diniz JS, Bouzada CF, Pereira A, Lopes T, Paixao G, Barros N, Figueiredo L, Cabral A, Silva AC, Oliviera E. Clinical Course of 822 Children with Prenatally Detected Nephrouropathies. Clin J Am Soc Nephrol. 2012: 7(3); 444–451
  25. Silva JM, Diniz JS, Silva AC, Azevedo MV, Pimenta MR, Oliveira EA.: Predictive factors of chronic kidney disease in severe vesicoureteral reflux. Pediatr Nephrol. 2006:21;1285–1292
  26. Smellie JM, Jodal U, Lax H, Mí¶bius TT, Hirche H, Olbing H, Writing Committee, International Reflux Study in Children (European Branch): Outcome at 10 years of severe vesicoureteric reflux managed medically: Report of the International Reflux Study in Children. J Pediatr. 2001:139; 656–663
  27. Wí¼hl et al. Timing and Outcome of RRT in CAKUT. Clin J Am Soc Nephrol. 2013:8; 67–74