Vol. 14 No. 2 (2022): Arch Pub Health
Clinical Science

The role of some inflammatory markers, cytokins and tumor markers in diagnosis of endometriosis

Online First pdf 58-71
  • Jadranka Georgievska,
  • Gligor Tofoski,
  • Goran Dimitrov,
  • Ana Daneva-Markova,
  • Viktorija Jovanovska,
  • Dragi Dabeski,
  • Sashe Jovcevski,
  • Elena Dzikova,
  • Aleksandra Atanasova
Jadranka Georgievska
University Clinic for Gynecology and Obstetrics; Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, Republic of North Macedonia
Gligor Tofoski
University Clinic for Gynecology and Obstetrics; Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, Republic of North Macedonia
Goran Dimitrov
University Clinic for Gynecology and Obstetrics; Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, Republic of North Macedonia
Ana Daneva-Markova
University Clinic for Gynecology and Obstetrics; Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, Republic of North Macedonia
Viktorija Jovanovska
University Clinic for Gynecology and Obstetrics; Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, Republic of North Macedonia
Dragi Dabeski
University Clinic for Gynecology and Obstetrics; Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, Republic of North Macedonia
Sashe Jovcevski
University Clinic for Gynecology and Obstetrics; Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, Republic of North Macedonia
Elena Dzikova
University Clinic for Gynecology and Obstetrics; Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, Republic of North Macedonia
Aleksandra Atanasova
University Clinic for Gynecology and Obstetrics; Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, Republic of North Macedonia
DOI: https://doi.org/10.3889/aph.2022.6060

Published 2022-12-30

Keywords

  • endometriosis,
  • inflammation,
  • cytokines,
  • interleukin,
  • serum tumor markers

How to Cite

1.
Georgievska J, Tofoski G, Dimitrov G, Daneva-Markova A, Jovanovska V, Dabeski D, Jovcevski S, Dzikova E, Atanasova A. The role of some inflammatory markers, cytokins and tumor markers in diagnosis of endometriosis. Arch Pub Health [Internet]. 2022 Dec. 30 [cited 2024 Dec. 14];14(2):58-71. Available from: https://id-press.eu/aph/article/view/6060

Copyright (c) 2022 Jadranka Georgievska, Gligor Tofoski, Goran Dimitrov, Ana Daneva-Markova, Viktorija Jovanovska, Dragi Dabeski, Sashe Jovcevski, Elena Dzikova, Aleksandra Atanasova

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Endometriosis is a multifactorial disease which etiopathogenesis has not been elucidated. One of the theories of etiopathogenesis is the inflammatory theory. Aims of the study: To develop a practical non-invasive test for the diagnosis of endometriosis by examining some inflammatory markers and cytokines; to compare the highly sensitive C-reactive protein (hsCRP), cytokines (interleukin-6-IL-6 and tumor necrotizing factor alpha) and the tumor marker cancer antigen 125 (CA-125) among healthy patients and patients with endometriosis; to determine the sensitivity and specificity of each biomarker separately in the diagnosis of endometriosis and to determine their role in the diagnosis of endometriosis. Materials and methods: In a prospective study conducted at the University Clinic for Gynecology and Obstetrics, Ss. Cyril and Methodius University in Skopje, North Macedonia 138 patients were included of a reproductive age between 18-50 years (83 with diagnosis endometriosis operated laparoscopically or with laparotomy) and a control group of 55 healthy women, in a period between 01.09.2018 to 01.05.2021. Serum levels of IL-6, TNF-α, hs-CRP and tumor marker CA-125 were evaluated in both groups. Results: Serum levels of CA-125, IL-6 and TNF-α and hs-CRP were significantly higher in patients with endometriosis compared to the control group. The surface under the ROC curve (AUC) for IL-6, CA-125, hs-CRP, and TNF-α has shown that as individual markers they all have a discriminatory capacity to diagnose patients with endometriosis. Conclusions: Results obtained in our study showed statistically significantly higher serum concentrations of CA-125, IL-6 and TNF-α and hs-CRP in patients with endometriosis compared to the control group of patients. However, none of these biomarkers showed a high sensitivity for diagnosis of endometriosis. It is necessary to find a panel combination of biomarkers with a high sensitivity of about 100% that will enable early diagnosis of endometriosis.

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