Vol. 15 No. 2 (2023): Arch Pub Health
Clinical Science

Insulin resistance and metabolic syndrome in hepatitis C virus seronegative heroin dependents

Online First pdf 47-59
  • Zanina Pereska,
  • Danijela Janicevic-Ivanovska,
  • Natasa Simonovska,
  • Aleksandra Babulovska,
  • Aneta Trajanovska-Spasovska,
  • Kiril Naumoski,
  • Kristin Kostadinoski
Zanina Pereska
University Clinic for Toxicology; Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, Republic of North Macedonia
Danijela Janicevic-Ivanovska
University Clinic for Clinical Biochemistry Skopje; Goce Delchev University-Shtip, Republic of North Macedonia
Natasa Simonovska
University Clinic for Toxicology; Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, Republic of North Macedonia
Aleksandra Babulovska
University Clinic for Toxicology; Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, Republic of North Macedonia
Aneta Trajanovska-Spasovska
Psychiatric Hospital Skopje; Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, Republic of North Macedonia
Kiril Naumoski
University Clinic for Toxicology; Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, Republic of North Macedonia
Kristin Kostadinoski
University Clinic for Toxicology; Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, Republic of North Macedonia
DOI: https://doi.org/10.3889/aph.2023.6110

Published 2023-12-25

Keywords

  • heroin dependents,
  • metabolic syndrome,
  • insulin resistance,
  • HOMA-IR,
  • HOMA-%B

How to Cite

1.
Pereska Z, Janicevic-Ivanovska D, Simonovska N, Babulovska A, Trajanovska-Spasovska A, Naumoski K, Kostadinoski K. Insulin resistance and metabolic syndrome in hepatitis C virus seronegative heroin dependents. Arch Pub Health [Internet]. 2023 Dec. 25 [cited 2024 Dec. 18];15(2). Available from: https://id-press.eu/aph/article/view/6110

Copyright (c) 2023 Zanina Pereska, Danijela Janicevic-Ivanovska, Natasa Simonovska, Aleksandra Babulovska, Aneta Trajanovska-Spasovska, Kiril Naumoski, Kristin Kostadinoski

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Initial studies on impaired glucose-insulin homeostasis in heroin dependents have not defined the impact of concomitant hepatitis C infection (HCV), which has been  strongly associated with the development of insulin resistanceand metabolic syndrome (MS). The aim of our study was to evaluate the association of heroin dependence with glucose-insulin homeostasis and MS in heroin dependents with HCV seronegativity. Materials and methods: The study was prospective and cross-sectional, including 160 heroin dependents compared to a control group of 60 participants.MS was diagnosed using International Diabetes Federation criteria. The homeostatic model assessment for insulin resistance (HOMA-IR) and pancreatic β-cell function (HOMA-%B) were used for assessing insulin resistance and β-cell function of pancreas. Results: MS was detected in 9.32% of heroin addicts. Heroin dependents with MS compared to dependents without MS were older, had higher BMI, waist circumference and significantly higher systolic and diastolic blood pressure, increased triglycerides (F=8.233, df=2, p<0.001), apoB (F=8.154, df=2, p=0.001), and reduced HDL-C (F=25.926, df=2, p<0.001) and apoA-I (F=16.406, df=2, p<0.001), significantly increased inuslinemia (F=4.928, df=2, p<0.05), insulin resistance-HOMA-IR (F=4,928, df=2, p<0,05) and insignificantly increased pancreatic β-cell function (194.66 ±224.05) (F=2.461, df=2, p>0.05). Conclusions: Insulin resistance and МS, independent of HCV, was also registered in heroin dependence. Timely recognition will enable more successful treatment of comorbidities and illicit drug dependence.

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