Vol. 12 No. 3 (2020): Archives of Public Health
Clinical Science

Аssessment of osteoporosis and occurrence of vertebral fractures in postmenopausal patients with rheumatoid arthritis treated with small doses of glucocorticoids

Maja Bojadzioska
University Clinic for Rheumatology; Faculty of Medicine, Ss. Cyril and Methodius University, Skopje
Petar Dejanov
University Clinic for Nephrology; Faculty of Medicine, Ss. Cyril and Methodius University, Skopje,
Irena Kafedziska
University Clinic for Rheumatology; Faculty of Medicine, Ss. Cyril and Methodius University, Skopje
Mimoza Nikolovska-Kotevska
University Clinic for Rheumatology; Faculty of Medicine, Ss. Cyril and Methodius University, Skopje
Andzelika Karadzova-Stojanoska
University Clinic for Rheumatology; Faculty of Medicine, Ss. Cyril and Methodius University, Skopje
Viktor Isjanovski
Psychiatric Hospital “Skopje”; Faculty of Medicine, Ss. Cyril and Methodius Universаity, Skopje
Sasha Jovanovska-Mishevska
University Clinic for Endocrinology; Faculty of Medicine, Ss. Cyril and Methodius University, Skopje
Filip Gucev
University Clinic for Rheumatology; Faculty of Medicine, Ss. Cyril and Methodius University, Skopje
Igor Isjanovski
University Clinic for Ophthalmology; Faculty of Medicine, Ss. Cyril and Methodius University, Skopje
Elena Curakova Ristovska
University Clinic for Gastroenterohepatology; Faculty of Medicine, Ss. Cyril and Methodius University, Skopje

Published 2020-12-15

Keywords

  • vertebral fractures,
  • rheumatoid arthritis,
  • glucocorticoids,
  • osteoporosis

How to Cite

1.
Bojadzioska M, Dejanov P, Kafedziska I, Nikolovska-Kotevska M, Karadzova-Stojanoska A, Isjanovski V, Jovanovska-Mishevska S, Gucev F, Isjanovski I, Curakova Ristovska E. Аssessment of osteoporosis and occurrence of vertebral fractures in postmenopausal patients with rheumatoid arthritis treated with small doses of glucocorticoids. Arch Pub Health [Internet]. 2020 Dec. 15 [cited 2021 Dec. 7];12(3):53-60. Available from: https://id-press.eu/aph/article/view/5608

Abstract

Osteoporosis (OP) is a serious extracorporeal manifestation that occurs in patients with rheumatoid arthritis (RA). One of the risk factors is long-term use of glucocorticoids (GC). Osteoporosis together with the increased risk of vertebral (VF) and non-vertebral fractures (non-VF) in particular has a negative impact on quality of life in patients with rheumatoid arthritis. The aim of the study was to detect the occurrence of OP and VF in postmenopausal patients with RA and their association with long-term use of small doses of glucocorticoids. Material and methods: A total of 46 patients were analyzed. All respondents underwent imaging for osteoporosis evaluation with a DXA scanner (Lunar iDXA, GE) and VF  with incorporated Vertebral Fracture Assessment (VFA). Results: The values of bone mineral densities (BMD) were significantly smaller in the group that received glucocorticoids. According to VFA, 37,0% of patients were registered to have a fracture of middle degree, a mild fracture was registered in 19.6% of patients, and severe fractures were registered in 3 patients (6.5%). Conclusion: In postmenopausal patients with RA receiving GC therapy, a more common occurrence of osteoporosis and vertebral fractures was reported compared with the remaining group of RA patients. All patients with RA in menopause need to be screened for timely detection and treatment of osteoporosis and prevention of its complications.

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