Vol. 10 No. 2 (2018): Archives of Public Health
Clinical Science

Analysis of maternal and obstetric risk factors for premature retinopathy in prematures whose weight was over 1500g and gestational age above 30 week

Igor Isjanovski
University Clinic for Eye Diseases, Faculty of medicine, University Ss. Cyril and Methodius Skopje, Republic of Macedonia
Viktor Isjanovski
Faculty of Medicine, University Ss. Cyril and Methodius Skopje, Republic of Macedonia

Published 2018-11-12

Keywords

  • risk factors,
  • retinopathy,
  • premature neonates

How to Cite

1.
Исјановски И, Исјановски В. Analysis of maternal and obstetric risk factors for premature retinopathy in prematures whose weight was over 1500g and gestational age above 30 week. Arch Pub Health [Internet]. 2018 Nov. 12 [cited 2022 Aug. 12];10(2):64-70. Available from: https://id-press.eu/aph/article/view/2245

Abstract

Retinopathy of Prematurity (ROP) is a major cause of preventable blindness in preterm infants. The incidence of ROP is increasing in developing countries due to increased survival of preterm infants. Retinopathy of prematurity (ROP) is a serious complication of prematurity and can lead to blindness unless is recognized and treated early. The aim of our study was to study maternal and obstetric risk factors for ROP. Material and methods: The research was an analytical "Case control" study in the period 2015-2016. The study included 163 premature babies that not meet the criteria of the American Academy of Ophthalmology (AAO), with BW more than 1500 g and gestational age more than 30 GW. Mothers were divided into two groups according the newborns with ROP and without. In order to achieve the goals, a two-part survey questionnaire was used, the first part of the questionnaire refers to questions for the mother.  Results: In Vitro Fertilization increases the chance of ROP two times OR=2.1256 (1.1133-4.0585). As independent factors, multiple pregnancies increase the chance of ROP for fourth times OR = 4.0721 (2.3899-9.2511). Preeclampsia acts protective, reduces the chance of occurrence of ROP OR = 0.2147 (0.0706-0.6526). The way of delivery, the number of pregnancies, number of births, alcohol consumption, smoking, narcotics, did not present as risk factors. Conclusions: We should pay attention to the definition of risk factors, their complexity, the development and progression of retinopathy prematurnata and its prevention, because they are just one of the issues facing ophthalmologists and neonatologists throughout his work. The study confirmed the same risk factors that are registered on neonatal premathuruses according to AАО (birth weight below 1500 g and under the 30th gestation week). Conclusion: Based on the analysis of the study, a conclusion and recommendation protocols criteria to screen for ROP to modify, despite inclusion criteria of AAО to include premature neonates in screening for ROP according to the recommendation of neonatologists to increased risk of premature retinopathy, with birth weight over 1500 g and over 30 gestation weeks.

Downloads

Download data is not yet available.

References

  1. Isjanovski I.& Golubovic M. Retinopathy of prematurity: some risk factors. Physioacta 2016; 10 (3): 63-70.
  2. Isjanovski I, Sazdovska S, Jordanova Dimovska V. Incidence and risk factors for retinopathy of prematurity. Physioacta 2017; 11(1):49-56.
  3. Исјановски И. Проценка на влијанието на Ин витро фертилизацијата во настанувањето на прематурната ретинопатија ( РОП ). Докторска дисертација, 2017. Медицински факултет Скопје, Универзитет Св. Кирли и Методиј.
  4. Wheatley C M, Dickinson J L, Mackey D A, Craig J E, Sale M M. Retinopathy of prematurity: recent advances in our understanding. Br J Ophthalmol 2002; 86(6): 696–700.
  5. Tasman W. Retinopathy of Prematurity: the life of a lifetime disease. Am J Ophthalmol 2006; 141(1): 167-74.
  6. Oros А, Otkrivanje, lecenje i prevencija razvoja Prematurne Retinopatije.Doktorska disertacija, Novi Sad, 2002
  7. Татеши Б. Прематурна ретинопатија-скрининг и современа терапија, докторска дисертација, Скопје, 2016. Медицински факултет Скопје, Универзитет Св. Кирли и Методиј.
  8. Das A. & McGuire PG. Retinal and Choroidal angiogenesis: pathophysiology and strategies for inhibition. Progress in Retinal and Eye Research 2003; 22(6):721-48.
  9. Gibson DL et al. Retinopathy of prematurity-induced blindness: birth weight-specific survival and the new epidemic. Pediatrics 1990; 86(3): 405-12.
  10. Phelps DL. Retinopathy of prematurity: an estimate of vision loss in the United States1979. Pediatrics 1981; 67(6): 924-5.
  11. Akeson N. & B. Bonapart. What is the current incidence of RLF. Pediatrics 1976; 58(4): 627.
  12. Silverman WA. Retrolental fibroplasia: a modern parable. Grune & Stratton1980. Retrieved 21 September 2013
  13. Silverman, William A. The Consequences of Oxygen Restriction. In: Retrolental fibroplasia: a modern parable. 1980. Grune & Stratton. Retrieved 21 September 2013.
  14. Watts P, Adams GG. In vitro fertilisation and stage 3 retinopathy of prematurity. Eye (Lond) 2000; 14:330–333.
  15. Cross KW. Cost of preventing retrolental fibroplasias. Lancet 1973; 2:954-956.
  16. Gilbert C, Rahi J, Eckstein M, O`Sullivan J, Foster A. Retinopathy of prematurity in middle-income countries. Lancet 1997; 350:954-956
  17. Gilbert C. Retinopathy of prematurity: A global perspective of the epidemics, population of babies at risk and implications for control. Early Human Develpoment 2008; 84:77-82.
  18. Hirabayashi H, Honda S, Morioka I, Yokoyama N, Sugiyama D, Nishimura K, Matsuo M, Negi A. Inhibitory effects of maternal smoking on the development of severe retinopathy of prematurity. Eye 2010; 24: 1024–1027
  19. Blanco CL, Baillargeon JG, Morrison RL, Gong AK. Hyperglycemia in extremely low birth weight infants in a predominantly hispanic population and related morbidities. J Perinatol 2006; 26:737–741.
  20. Ertl T, Gyarmati J, Gaal V, Szabo I. Relationship between hyperglycemia and retinopathy of prematurity in very low birth weight infants. Biol Neonate 2006; 89:56–59.
  21. Garg R, Agthe AG, Donohue PK, Lehmann CU.Hyperglycemia and retinopathy of prematurity in very low birth weight infants. J Perinatol 2003; 23:186–194.
  22. Bergh T, Ericson A, Hillensjo T, Nygren KG, Wennerholm UB. Deliveries and children born after in-vitro fertilisation in Sweden 1982–95: a retrospective cohort study. Lancet 1999; 354: 1579–1585.
  23. Friling R, Axer-Siegel R, Hersocovici Z, Weinberger D, Sirota L, Snir M. Retinopathy of prematurity in assisted versus natural conception and singleton versus multiple births. Ophthalmology 2007; 114(2):321-324.
  24. Watts P, & Adams GGW. In vitro fertilisation and stage 3 retinopathy of prematurity. Eye 2000; 14: 330-333.
  25. Blumenfeld LC, Siatowski RM, Feuer WJ, et al. Retinopathy of prematurity in multiple-gestation pregnancies. Am J Ophthalmol 1998;125:197–203.
  26. Kumar MA., Rajalakshmi AR, Gunasekaran D, Sreeraaganidhi. A study of risk factors for retinopathy of prematurity in a medical college hospital in South India to evaluate the criteria for screening for retinopathy of prematurity. Journal of current trends in clinical medicine & laboratory biochemistry 2014; 2(2): 31-36.
  27. Seiberth V & Linderkamp O. Risk factors in retinopathy of prematurity. A multivariate statistical analysis. Ophthalmologica 2000; 214(2):131–135.
  28. Shah VA, Yeo CL, Ling YL. Incidence, risk factors of retinopathy of prematurity among very low birth weight infants in Singapore. Ann Acad Med Singapore 2005; 34:169-78.
  29. Stanković BG, Oros А, Vujanović М, Cekić S, Jonović M. Some of the risk factors for retinopathy of prematurity. Acta Medica Medianae 2014; 53(3): 5-10.
  30. Zayed MA, Uppal A, Hartnett ME. New-onset maternal gestational hypertension and risk of retinopathy of prematurity. Invest Ophthalmol Vis Sci 2010; 51(10): 4983–4988.
  31. Fortes Filho JB, Costa MC, Eckert GU, Santos PG, Silveira RC, Procianoy RS. Maternal preeclampsia protects preterm infants against severe retinopathy of prematurity. J Pediatr 2011; 158(3): 372–376.
  32. Dhaliwal CA, Fleck BW, Wright E, Graham C, McIntosh N. Retinopathy of prematurity in small-for-gestational age infants compared with those of appropriate size for gestational age. Arch Dis Child Fetal Neonatal Ed 2009; 94(3): F193–F195
  33. Palmer EA, Flynn JT, Hardy RJ, et al. The cryotherapy for retinopathy of prematurity cooperative group. Incidence and early course of retinopathy of prematurity. Ophthalmology 1991; 98(11):1628–1640.
  34. Gebesce Arzu et al. Retinopathy of prematurity: incidence, risk factors, and evaluation of screening criteria, Turk J Med Sci 2016; 46: 315-320.
  35. Özkan H, Çetinkaya M, Koksal N, Özmen A, Yıldız M. Maternal preeclampsia is associated with an increased risk of retinopathy of prematurity. J Perinat Med 2011; 39: 523–527.
  36. Tunay ZÖ, Özdemir Ö, Acar DE, Öztuna D3, Uraş N. Maternal diabetes as an independent risk factor for retinopathy of prematurity in infants with birth weight of 1500 g or more. Am J Ophthalmol 2016;168:201-206.